Lap Lambert Academic Publishing NSAID Prodrugs: Synthesis, Characterization and vivo Evaluation: Amide and Ester Prodrugs of Ibuprofen, Naproxen, Aceclofenac, and Diclofenac Broché

This book presents a systematic study on the design, synthesis, characterization, and pharmacological evaluation of novel prodrugs derived from selected NSAIDs, including ibuprofen, naproxen, aceclofenac, and diclofenac. The work focuses on the preparation of amide and ester derivatives to explore their structural and biological properties. Detailed synthetic methods and reaction conditions are discussed, followed by characterization of the synthesized compounds using FT-IR and ¹H NMR spectroscopy. FT-IR analysis is used to identify characteristic functional groups, while ¹H NMR spectroscopy provides important information about the chemical environment and structural features of the synthesized derivatives. The prepared prodrugs are further evaluated through in vivo pharmacological studies, particularly for analgesic and anti-inflammatory activities. The book integrates medicinal chemistry, synthetic chemistry, spectroscopic characterization, and pharmacological evaluation, providing a concise research-oriented resource for students, researchers, and academicians working in pharmaceutical and medicinal chemistry.